University of Arizona Health Sciences researchers received a $13.1 million grant from the National Institute on Aging to continue studies aimed at rejuvenating the immune system of older people in order to improve health throughout the lifespan.
Older adults are disproportionally affected by infection, cancer and certain types of autoimmune disease. This is influenced by the fact that as a person ages, their body produces fewer T cells and gets less proficient at maintaining them. T cells are a type of white blood cell essential to the immune system and defense against infection.
The goal of the National Institutes of Health-funded research is to contribute to the fundamental knowledge of T cell aging and create interventions to improve immune defense. The program consists of three research studies and four supporting cores that span multiple sites across the country. The thymus gland has a remarkable capacity for bouncing back from acute injury caused by infection, shock or chemotherapy, but this ability deteriorates with age. The project will focus on enhancing thymic regeneration in older individuals, which could result in clinical approaches to enhance the immune system.
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