Why the pros consider serums “medicine” for your skin and vitamin C “the LBD of skincare.”
There can be confusion around the role of serums in a skincare routine and whether they’re worth investing in, but with the number of solution-based serums out there, one-size-fits-all products are a thing of the past.
The key to using serums? Keeping a consistent routine and paying close attention to how your skin responds. Below you’ll find an expert’s guide to the best new serums for all skin concerns.
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Exogenous mitochondrial transplantation improves survival and neurological outcomes after resuscitation from cardiac arrest - BMC MedicineBackground Mitochondrial transplantation (MTx) is an emerging but poorly understood technology with the potential to mitigate severe ischemia–reperfusion injuries after cardiac arrest (CA). To address critical gaps in the current knowledge, we test the hypothesis that MTx can improve outcomes after CA resuscitation. Methods This study consists of both in vitro and in vivo studies. We initially examined the migration of exogenous mitochondria into primary neural cell culture in vitro. Exogenous mitochondria extracted from the brain and muscle tissues of donor rats and endogenous mitochondria in the neural cells were separately labeled before co-culture. After a period of 24 h following co-culture, mitochondrial transfer was observed using microscopy. In vitro adenosine triphosphate (ATP) contents were assessed between freshly isolated and frozen-thawed mitochondria to compare their effects on survival. Our main study was an in vivo rat model of CA in which rats were subjected to 10 min of asphyxial CA followed by resuscitation. At the time of achieving successful resuscitation, rats were randomly assigned into one of three groups of intravenous injections: vehicle, frozen-thawed, or fresh viable mitochondria. During 72 h post-CA, the therapeutic efficacy of MTx was assessed by comparison of survival rates. The persistence of labeled donor mitochondria within critical organs of recipient animals 24 h post-CA was visualized via microscopy. Results The donated mitochondria were successfully taken up into cultured neural cells. Transferred exogenous mitochondria co-localized with endogenous mitochondria inside neural cells. ATP content in fresh mitochondria was approximately four times higher than in frozen-thawed mitochondria. In the in vivo survival study, freshly isolated functional mitochondria, but not frozen-thawed mitochondria, significantly increased 72-h survival from 55 to 91% (P = 0.048 vs. vehicle). The beneficial effects on survival were associated with impr
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Why the UK should inject some fizz into carbon capture\n\t\t\tLet our global subject matter experts broaden your perspective with timely insights and opinions you\n\t\t\tcan’t find anywhere else.\n\t\t
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Why the UK should inject some fizz into carbon capture\n\t\t\tLet our global subject matter experts broaden your perspective with timely insights and opinions you\n\t\t\tcan’t find anywhere else.\n\t\t
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Why British bookshelves will soon be heaving under the weight of steamy titlesReaders can expect a bounty of erotic fiction, memoir and relationship guides, and titles with a greater focus on inclusivity than traditional mainstream offerings
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I'm a doctor and here’s why rubbing your eyes can trigger fatal infectionsA QUICK rub at your eye after a long day or if you’ve got some dust stuck in it might not seem like a big deal. But doctors say it’s never a good idea to do this. Here are nine reasons …
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Why Triple Eight's Newcastle disqualification was upheldMotorsport Australia has released the full findings of its Melbourne hearing, explaining why it upheld Triple Eight's disqualification from Newcastle 500. RepcoSC
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