itemprop=description content=Researchers utilize 3D printing to craft cerebral cortex tissues with organized neurons, offering potential treatments for brain injuries. This novel technique prints neural progenitors in layer-by-layer sequences, aiming for accurate tissue restoration in damaged brains.
By Neha MathurOct 8 2023Reviewed by Sophia Coveney A recent study published in Nature Communications demonstrated how droplet-based three-dimensional printing could help fabricate cerebral cortex tissues comprising layer-specific neurons organized into vertical columns.
Thus, the implantation of tissues resembling the cellular architecture of the damaged tissue could be more effective than dissociated hiPSC-derived organoids lacking structural integrity. Related StoriesThey printed the tissues in oil before conducting an extended treatment of NPs. They incubated cortical tissues in Neural Maintenance Medium supplemented with a growth factor cocktail comprising growth factors that support proliferation and survival for the first week of post-printing culture .
Results The researchers observed neuron migration and maturation during in vitro culture after printing for over a week. Finally, when the researchers implanted the printed cortical tissues into ex vivo brain explants, the implant formed structural connections with the host tissues and maintained its calcium ion activity.
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