Researchers at the IBB-UAB have developed the most comprehensive database available to date to help understand the basis of protein aggregation, a phenomenon associated with aging and several pathologies.
Reviewed by Megan Craig, M.Sc.Nov 3 2023 The new resource, A3D-MOBD, brings together the proteomes of twelve of the most studied model organisms which cover distant biological clades and contains over half a million predictions of protein regions with a propensity to form aggregates.
The new resource builds on the method that the same research group designed in 2015, Aggrescan 3D, but significantly expands the obtainable data. In total, it contains more than 500,000 structural predictions for more than 160,000 proteins from twelve highly characterized model organisms of great interest and widely used biology, biotechnology and biomedicine research.
Protein aggregation is associated with aging and is the basis of different pathologies, such as Parkinson's disease, Alzheimer's disease and amyotrophic lateral sclerosis . It is also one of the most important barriers in the industrial production of therapeutic molecules, increasing their final price.
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