A human interactome to prioritize drugdiscovery NatureGenet
In the present study, the researchers showed that the interactome could be used to find the proteins most likely to be involved in causing disease, using Inflammatory Bowel Disease as an example. IBD is a complex disease with a genetic basis, but for which the disease biology is not well understood.
"This work bridges many fields of biology, including statistical genetics, cell biology, and bioinformatics," said Pedro Beltrao, Associate Professor at ETH Zurich and former Group Leader at EMBL-EBI."It brought together groups from across Open Targets and EMBL-EBI, and highlights the value of collaborations across disciplines."
"This is an exciting showcase of one of our Open Targets collaborative informatics projects that has generated an array of new insights for novel target discovery as well as drug repurposing, and informs our understanding of the connection between rare and common diseases through shared biological processes," said Ellen McDonagh, Director of Informatics Science at Open Targets.
"This is now being developed further to provide tissue and cell-type specific networks to help further prioritize targets for disease treatment."Pedro Beltrao, Network expansion of genetic associations defines a pleiotropy map of human cell biology,
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