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Research led by USC indicates that a high-fat, sugary diet in adolescence can cause persistent memory impairments, despite later dietary improvements, highlighting a significant, long-term impact on brain function and memory.researchers, which observed rats on a high-fat and sugary diet, suggests that consuming a lot of junk food during teenage years might have long-lasting effects on memory function.
The team wondered what this could mean for younger people who may be on a similar fat-filled, sugary Western diet, particularly during adolescence when their brain is undergoing significant development. By tracking the impact of the diet on the rats’ levels of acetylcholine, and running the rats through some memory testing, they could learn more about the important relationship between diet and memory.
“Acetylcholine signaling is a mechanism to help them encode and remember those events, analogous to ‘episodic memory’ in humans that allows us to remember events from our past,” lead author Hayes explained. “That signal appears to not be happening in the animals that grew up eating the fatty, sugary diet.”
There is at least some hope for intervention. Kanoski said that in another round of the study, the research team examined whether the memory damage in rats raised on the junk food diet could be reversed with medication that induces the release of acetylcholine. They used two drugs, PNU-282987, and carbachol, and found that with those treatments given directly to the hippocampus, a brain region that controls memory and is disrupted in Alzheimer’s disease, the rats’ memory ability was restored.
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