A new report examines the safety of bivalent COVID boosters among 1.7 million over-50s Coronavirus Disease COVID bivalent boosters medrxivpreprint SSI_dk koebenhavns_uni
Bivalent messenger ribonucleic acid boosters targeting the ancestral SARS-CoV-2 and the Omicron BA.1 or BA.4/5 spikes were approved for use in 2022. These bivalent boosters were recommended following primary vaccination regardless of boosting with monovalent vaccines.
Study: Safety of bivalent omicron-containing mRNA-booster vaccines: a nationwide cohort study. Image Credit: Jo Panuwat D / Shutterstock The team evaluated the potential risk of 27 adverse events for SARS-CoV-2 vaccines. Outcome events were hospital visits, where outcome diagnoses were the main reasons to seek hospital care. Subjects were followed up from day 29 post-third/fourth dose until the first outcome, emigration, death, or study’s end.
Findings Overall, more than 2.2 million triple-vaccinated individuals were included in the cohort; their average age was 66.9 years, and most individuals were females. Among these, over 1.7 million subjects were boosted with the bivalent vaccine between September 15 and December 10, 2022.
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