A novel discovery in the field of pancreatic cancer treatment has been unveiled, revealing the epigenetic silencing of BEND4 as a potential synthetic lethal marker for enhancing the efficacy of ATM inhibitors in pancreatic cancer treatment.
Frontiers JournalsNov 5 2024 This innovative research provides a groundbreaking approach to targeting a tumor suppressor gene, BEND4, which is frequently methylated and silenced in pancreatic cancer . The study delves into the role of BEND4 in DNA damage repair and its potential as a therapeutic marker when combined with ATM inhibitor treatment.
The study demonstrated that BEND4 suppresses cell growth, induces G1/S arrest and apoptosis, and inhibits migration and invasion in PDAC cells. The underlying mechanism involves BEND4's interaction with Ku80, a key player in the non-homologous end joining pathway, which is a major DNA double-strand break repair pathway.
DNA DNA Damage Gene Pancreatic Cancer Cancer Treatment Cell Efficacy In Vivo Research Tumor
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