Malaria kills over 600,000 people a year, and as the climate warms, the potential range of the disease is growing. While some drugs can effectively prevent and treat malaria, resistance to those drugs is also on the rise.
University of Utah HealthOct 29 2024
We still don't really understand how parasites acquire iron in the red blood cell, which is rather ironic given that it's the most iron rich cell in the human body." Researchers knew that the malaria parasites had to harvest iron-rich hemoglobin from human blood cells, crack it open to get at the iron inside, and move the iron to the parts of the parasite that need it.
Importantly, they found that DMT1 is absolutely critical for parasite survival. The researchers edited the malaria parasites' genome so that they could turn off DMT1 protein production at will. When they turned DMT1 off, the parasites died before being able to infect more blood cells-;an unusually rapid demise, even for the loss of an essential protein.
Protein Biochemistry Blood Cell Drugs Medicine Metabolism Microscope Red Blood Cells Research
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