A rare voice box transplant helped a cancer patient speak again, part of a pioneering study

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A rare voice box transplant helped a cancer patient speak again, part of a pioneering study
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A Massachusetts man can speak again after surgeons removed his cancerous voice box and replaced it with a donated one, a pioneering move.

In this photo provided by the Mayo Clinic, Marty Kedian poses for a photo in Mayo Clinics Head and Neck Regenerative Medicine Laboratory in Scottsdale, Ariz., on June 12, 2024. Kedian regained his voice after surgeons removed his cancerous larynx and, in a pioneering move, immediately replaced it with a donated one. – A Massachusetts man has regained his voice after surgeons removed his cancerous larynx and, in a pioneering move, replaced it with a donated one.

He became emotional recalling the first time he phoned his 82-year-old mother after the surgery “and she could hear me. … That was important to me, to talk to my mother.” The first two U.S. larynx transplant recipients – at the Cleveland Clinic in 1998 and the University of California, Davis, in 2010 – had lost their voices to injuries, one from a motorcycle accident and the other damaged by a hospital ventilator.

“We want to be able to push those boundaries but do it as safely and ethically as we can,” Lott said. But Belafsky said there's “still a shot” for larynx transplants to become more common while cautioning it likely will take years more research. One hurdle has been achieving enough nerve regrowth to breathe without a trach tube.

Then Kedian’s wife Gina tracked down the Mayo study. Lott decided he was a good candidate because his cancer wasn’t fast-growing and -- especially important -- Kedian already was taking antirejection drugs for an earlier kidney transplant.Then on Feb. 29, six surgeons operated for 21 hours.

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