These UK holiday homes are breath-takingly beautiful. AD VrboUK Vrbo 2022UKVrboOfTheYear holidayhome UKstaycation
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Thursford Castle sums up a Norfolk hideaway to a tee – you really wouldn't know it was there, unless you were fortunate enough to be in on the secret. Scotland End Barn comes with all the amenities for shared time, such as a dedicated games room and bi-fold doors in the living area that open out to the west facing terrace where you can enjoy beautiful sunsets all year round. The house is flooded by light with floor to ceiling glass windows and it has homely touches everywhere, such as artwork and a bookshelf filled with great novels for lazy days.
The property comes with its own bar with a 75’’ flat screen TV and a games area with pool table. Sleeps 25 , from £5,324 for 3 nights.Nothing says unforgettable family holiday like a stay in Carnell, a 500-year-old Scottish castle from the Wallace Clan.
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Adiposity and grip strength: a Mendelian randomisation study in UK Biobank - BMC MedicineBackground Muscle weakness, which increases in prevalence with age, is a major public health concern. Grip strength is commonly used to identify weakness and an improved understanding of its determinants is required. We aimed to investigate if total and central adiposity are causally associated with grip strength. Methods Up to 470,786 UK Biobank participants, aged 38–73 years, with baseline data on four adiposity indicators (body mass index (BMI), body fat percentage (BF%), waist circumference (WC) and waist-hip-ratio (WHR)) and maximum grip strength were included. We examined sex-specific associations between each adiposity indicator and grip strength. We explored whether associations varied by age, by examining age-stratified associations (| 50 years, 50–59 years, 60–64 years,65 years +). Using Mendelian randomisation (MR), we estimated the strength of the adiposity–grip strength associations using genetic instruments for each adiposity trait as our exposure. Results In males, observed and MR associations were generally consistent: higher BMI and WC were associated with stronger grip; higher BF% and WHR were associated with weaker grip: 1-SD higher BMI was associated with 0.49 kg (95% CI: 0.45 kg, 0.53 kg) stronger grip; 1-SD higher WHR was associated with 0.45 kg (95% CI:0.41 kg, 0.48 kg) weaker grip (covariate adjusted observational analyses). Associations of BMI and WC with grip strength were weaker at older ages: in males aged | 50 years and 65 years + , 1-SD higher BMI was associated with 0.93 kg (95% CI: 0.84 kg, 1.01 kg) and 0.13 kg (95% CI: 0.05 kg, 0.21 kg) stronger grip, respectively. In females, higher BF% was associated with weaker grip and higher WC was associated with stronger grip; other associations were inconsistent. Conclusions Using different methods to triangulate evidence, our findings suggest causal links between adiposity and grip strength. Specifically, higher BF% (in both sexes) and WHR (males only) were associated with weaker grip streng
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