A new study found a link between an increased risk of developing migraines and the use of acid reflux medications, such as proton pump inhibitors. Here's what you need to know about the research.
Kaitlin Vogel is a health journalist based in New York. Her work has appeared in a variety of publications, including Healthline, Eating Well, Parade, and more.Nick Blackmer is a librarian, fact-checker, and researcher with more than 20 years of experience in consumer-facing health and wellness content.
People who took proton pump inhibitors, the most commonly used acid reflux medications, had the highest odds of developing migraine.Now, a new study suggests that taking medications to ease symptoms may increase the risk of another painful condition: migraines. The research adds to growing evidence suggesting that acid-suppressing medications have a connection to migraines and severe headaches.
Participants reported whether they took PPIs, H2 receptor antagonists , and generic antacids. Researchers discovered that, compared to people who didn’t take acid reflux medications, those taking H2RAs and generic antacids had a respective 40% and 30% higher chance of developing a migraine or severe headache within three months. Participants who used PPIs had an increased migraine risk of 70%.
According to Mikhael, acid reflux may spur a migraine through an “inflammatory cascade reaction that starts at the GI level” and triggers the central nervous system to “facilitate the release of the calcitonin gene-related peptides.”“Patients with increased life stress would be expected to produce more acid as a stress response, which is what I see in clinical practice,” he explained. “Patients with increased life stress would also be expected to have more frequent headaches.
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