A Review published in Crit_Care suggests that in acute-on chronic liver failure patients, standardization of the treatment paradigm is required for different disease stages that may provide targeted treatment strategies for individual needs.
]. Meanwhile, the current evolution of ACLF clinical management involves the emergence of potential therapeutic strategies. This review provides an updated summary of the diagnostic criteria and prognostic scores proposed by different scientific societies, the underlying pathophysiology of ACLF and its treatment.In the past decade, several definitions of ACLF have been proposed by international consortia .
Table 1 Definitions, diagnostic criteria and stratification of ACLF proposed by each of the four major international scientific consortiaTo define ACLF as a distinct syndrome, a multicentre, prospective and observational CANONIC study, involving 1343 patients nonelectively hospitalized for acute decompensation of cirrhosis with or without prior decompensation, was performed in Europe to determine the characteristics of patients with OFs; a ≥ 15% mortality rate at 28 days was observed [].
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