Addressing research gaps: The UK's efforts to study lung cancer in never smokers Nature uniofleicester researchgaps lungcancer cancer lung smokers neversmokers publichealth
By Neha MathurJul 25 2023Reviewed by Lily Ramsey, LLM In a recent study published in BJC Reports, the Committee members of the National Cancer Research Institute’s Lung Group in the United Kingdom surveyed to understand the specific needs of lung cancer in never smokers patients, which are distinct from the needs of a smoking lung cancer population.
Background LCINS accounts for 15% of lung cancers diagnosed in the UK, with estimated deaths of 6,000/year, making it the eighth most common cancer in the UK if considered a distinct disease entity. LCINS occur in ‘never-smokers,’ individuals who smoked <100 cigarettes throughout their life. This survey comprised six categories within which responders listed their top five research questions. The categories covered were basic science, prevention, early screening/detection, diagnosis, treatment, and survivorship.
A national-level media awareness campaign could address this gap; for instance, there should be explicit information that one could get lung cancer despite good health, diet, and exercise potential. A prospective study among UK women found that non-white ethnicity, asthma requiring treatment, and taller stature increased the LCINS risk. It is more common in women and some ethnic groups.
Disease biology Most large-scale multi-omics studies on lung cancer have focused on smoking-associated mutational signatures of lung cancer, especially adenocarcinoma, the dominant pathological subtype; however, LCINS signatures are distinct from lung cancer in ever smokers . More than environmental triggers, ancestry triggered somatic mutational profiles, impacting the interpretation of tumor mutational burden and the efficacy of immuno-therapeutics.
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