Researchers find possible target for treating neuropsychiatricdisorders in teens elife
animals within postnatal days P21-P25. CNO was injected 1 time per day for three days into the animals within postnatal days P35-P42. For one-day-after tests, animals were tested on the Y-maze 1 day after the last injection day. For adulthood tests, animals were tested at 2∼3-month age on the Y-maze. Some of the adult animals were also tested for amphetamine induced locomotion as described above.
CNO stimulation of DREADD-Gq in midbrain dopamine neurons and imaging of mesofrontal axons and boutons Animals were prepared for surgery as described above. A mixture of 0.4 µl of pAAV8-hSyn-DIO-hM3D-mCherry or pAAV8-hSyn-DIO-mCherry 0.5 µl AAV2/9-phSyn1-Flex-tdTomato-T2A-SynEGFP-WPRE and 0.3 µl AAV9.CAG.Flex.tdTomato.WPRE.bGH was injected into the midbrain region ofanimals within postnatal days P21-P25. The procedure was later modified with a 0.6 µl of pAAV8-hSyn-DIO-hM3D-mCherry or pAAV8-hSyn-DIO-mCherry first and then immediately followed by an injection of a mixture of 0.
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