Researchers examine the relationships between neuropsychiatric and cognitive polygenic scores, attention-related phenotypes, and psychosis symptoms.
By Tarun Sai LomteReviewed by Benedette Cuffari, M.Sc.Nov 1 2024 Study reveals genetic links between attention deficits, functional brain connectivity, and early psychosis risk in adolescents.
Attention deficits and schizophrenia risk Attention problems often present long before psychotic symptom onset in people who later develop schizophrenia . In fact, attention deficits are among the earliest signs of psychosis risk; therefore, attentional impairment and neurodevelopmental alterations may reflect a genetic predisposition to SCZ.
Data were obtained from 11,855 children from the adolescent brain cognitive development study, which monitored individuals between nine and eleven years of age at baseline for 10 years. Individuals with symptoms aligning with psychosis-spectrum disorders were included in the study. A summary score for PQ-BC distress was calculated as a measure of PLEs. All study participants underwent brain magnetic resonance imaging . Within- and between-network functional connectivity was determined using pairwise correlations.
Study findings Altered FC and greater IIV were associated with more severe PLEs. Greater IIV was associated with increased PLE severity, according to the PQ-BC distress score. A weaker anticorrelation between DMN and DAN, as well as between DMN and CON, was significantly associated with the severity of PLEs.
PGSs were not associated with the DAN-DMN anticorrelation or within-network FC of the DAN. Notably, IIV-mediated associations between cognitive, Neurodev, and ADHD PGSs and PLEs were involved in 4-16% of these relationships.
Genetic Brain Genome Mental Health Psychosis Schizophrenia
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