A collaborative study led by researchers from Germans Trias i Pujol Research Institute has revealed the promising possibilities of using an agarose spot migration assay to examine the ability of extracellular vesicles to attract other cells in a controlled environment. The study has been recently published in the journal BMC Biology.
A collaborative study led by researchers from Germans Trias i Pujol Research Institute has revealed the promising possibilities of using an agarose spot migration assay to examine the ability of extracellular vesicles to attract other cells in a controlled environment. The study has been recentlywhich are present in various biological processes, including cellular communication.
The study led by researchers from IGTP's research groups Innovation in Vesicles and Cells for Application in Therapy , Badalona Applied Research Group in Oncology and Resistance, Chemotherapy and Predictive Biomarkers emphasizes how EVs can influence cancer metastasis.
High pro-metastatic PC3 and low pro-metastatic LNCaP cell lines recruitment by their own EVs embedded in agarose spots. Credit: IGTPThe first author of the study, Marta Clos-Sansalvador, a predoctoral student from IGTP's group IVECAT, explains that"the agarose spot migration assay may offer a diversity of measurements and migration settings not provided by classical migration assays, like scratch assays, and reveal its potential use in the EV and cancer metastasis fields.
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