A novel study by researchers at the Icahn School of Medicine at Mount Sinai addresses a critical yet under-explored question in cancer research: Why is aging the biggest risk factor for cancer? The study reveals how an aging immune system spurs tumor growth, offering new insights into cancer prevention and treatment, especially for older adults.
The Mount Sinai Hospital / Mount Sinai School of Medicine Sep 6 2024
As the immune system ages, it triggers harmful inflammation that can drive cancer growth––by promoting the accumulation of pro-tumor macrophages, a type of immune cell that suppresses the immune effector cells that normally kill tumor cells. This weakens the body's ability to fight cancer.
Cancer is a disease that becomes increasingly common as we age, with the risk rising sharply after the age of 60. Many theories have been proposed, including the cumulative effects of environmentally-induced damage and genetic mutations, but there has been little concrete data explaining why aging drives cancer, say the researchers.
Using high-dimensional analysis of murine and human cancer tissues, the team identified specific cells and immune-related factors that accelerate cancer growth in the elderly. They then successfully blocked these factors, specifically IL-1⍺/β, demonstrating that inhibiting these molecules can reduce cancer growth in aged mice.
Cancer Immune System Arthritis Bone Bone Marrow Cancer Prevention Cell Hospital Immunology Immunotherapy Inflammation Interleukin Lung Cancer Medicine Preclinical Research Rheumatoid Arthritis Tumor
United Kingdom Latest News, United Kingdom Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Novel study reveals how aging immune system fuels cancer growth, potentially opening new avenues for preventionA novel study by researchers at the Icahn School of Medicine at Mount Sinai addresses a critical yet under-explored question in cancer research: Why is aging the biggest risk factor for cancer? The study reveals how an aging immune system spurs tumor growth, offering new insights into cancer prevention and treatment, especially for older adults.
Read more »
John Swinney dumps universal free school meals promise for primary school kidsThe commitment was made last year, but has been binned by the First Minister.
Read more »
Parents fear children 'could starve' as school issues warningParents received a letter from the school about school meals
Read more »
Five school uniform hacks to help parents save money as kids return to schoolA childrenswear expert has shared five school uniform hacks to help parents save money as the new academic year looms large
Read more »
The two city schools set for expansion as new plans unveiledGlade Hill Primary School and Rise Park Primary and Nursery School both require increased SEND facilities
Read more »
'Perfect for school run' Skechers slashed by £18 in Amazon back-to-school saleThese Skechers Women's Summit Artistry Chic trainers are being hailed as a 'must-have for back-to-school' by shoppers as they are 'so comfortable and supportive'.
Read more »