Insilico Medicine ('Insilico'), a clinical-stage generative artificial intelligence (AI)-driven drug discovery company, announced that it has received IND clearance from FDA for ISM5939, a potential best-in-class oral small molecule inhibitor targeting ENPP1 for the treatment of solid tumors.
InSilico Medicine Nov 22 2024 Insilico Medicine , a clinical-stage generative artificial intelligence -driven drug discovery company, announced that it has received IND clearance from FDA for ISM5939, a potential best-in-class oral small molecule inhibitor targeting ENPP1 for the treatment of solid tumors. The achievement marks the 10th AI-driven molecule self-developed by Insilico to be recognized with clearance to enter clinical trials.
In May 2023, Insilico Medicine announced the nomination of ISM5939 as a preclinical candidate compound targeting ENPP1, with the potential for cancer immunotherapy. According to preclinical data, ISM5939 demonstrated robust anti-tumor efficacy in in vivo studies, while showing favorable safety profile, as well as in vitro ADMET and in vivo pharmacokinetic profiles.
Powered by Chemistry42, Insilico's proprietary generative chemistry engine affiliated to Pharma.AI, Insilico obtained the lead compound with a distinctly novel molecular structure within 3 months of project initiation, after dedicated optimization through structural modifications by Insilico's medicinal chemists.
Artificial Intelligence Biotechnology Cancer Compound Drug Discovery In Vivo Molecule Preclinical Tumor
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