Two bioactive, natural-derived compounds, which show activity at the GLP-1R site, may be orally administered with fewer side effects than their pharmaceutical counterparts.
-like-peptide-1 receptor agonists for weight loss as possible alternatives to pharmaceutical weight-loss drugs, but with potentially fewer side effects and oral administration.
Presenter Elena Murcia, PhD, of the Structural Bioinformatics and High-Performance Computing Research Group & Eating Disorders Research Unit, Catholic University of Murcia, Murcia, Spain, will be sharing her work at the upcoming In addition, there is the issue of having to inject the drugs rather than taking them orally due to the peptide nature of existing GLP-1 agonists that risk degradation by stomach enzymes before they exert the required effect.
Other recent research has highlighted two promising non-peptide compounds, TTOAD2 and orforglipron. "These are synthetic, and we were interested in finding natural alternatives," she added.Drawing on recent understanding around the TTOAD2 and orforglipron compounds, the present work focuses on using AI to identify new non-peptidic, natural-derived bioactive compounds to activate the GLP-1R, according to the researcher in her abstract and a preconference press release from ECO.
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