Researchers have developed a new generative artificial intelligence (AI) tool that models the infant microbiome. This 'digital twin' of the infant microbiome creates a virtual model that predicts the changing dynamics of microbial species in the gut, and how they change as the infant develops.
Researchers have developed a new generative artificial intelligence tool that models the infant microbiome. This 'digital twin' of the infant microbiome creates a virtual model that predicts the changing dynamics of microbial species in the gut, and how they change as the infant develops.
"You can only get so far by looking at snapshots of the microbiome and seeing the different levels of how many bacteria are there, because in a preterm infant, the microbiome is constantly changing and maturing," said Ishanu Chattopadhyay, PhD, Assistant Professor of Medicine and senior author of the new study, published in."So, we developed a new approach using generative AI to build a digital twin of the system that models the interactions of the bacteria as they change.
The model also indicated that interventions like restoring the abundance of a particular bacterial species could reduce the developmental risk of about 45% of the babies. The authors caution, however, that the model also showed that incorrect interventions can make the risk worse. Chattopadhyay's research partners, like co-author Erika Claud, MD, Professor of Pediatrics and Director of the Center for the Science of Early Trajectories are working with bioreactors that simulate the live gut microbiome environment where they can test out potential interventions and see what happens.
Nicholas Sizemore, Kaitlyn Oliphant, Ruolin Zheng, Camilia R. Martin, Erika C. Claud, Ishanu Chattopadhyay.Infant gut microbiomes oscillate with a circadian rhythm, even when they are cultivated outside of the body. Researchers report that the rhythm is detectable as early as 2 weeks after birth but ...
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