Skin cancer rewires its energysystems to spread more efficiently, finds study QMUL NatureComms
. NMR spectroscopy was performed on a Bruker Avance NEO 600 MHz NMR spectrometer equipped with a TCI Prodigy CryoProbe . Spectra were acquired at 298 K and consisted for each sample of a 1D, which was then phase corrected, baseline corrected and the chemical shifts were referenced to the TSP peak at 0.0 ppm.
. To determine whether spectra cluster into groups, PLS-DA with k-fold cross-validation were performed. PLS-DA of the full 1DH spectrum, after alignment, normalization using PQN, and log-scaling of the spectra was done.
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Study finds association between long-term exposure to air pollution and severe COVID-19A long history of exposure to air pollution is associated with a higher risk of developing severe disease, admission to hospital or an intensive care unit (ICU) and death by COVID‑19 according to a study led by the Barcelona Institute for Global Health (ISGlobal). The study, published in the journal Nature Communications, was based on a large cohort of 4,660,502 adults resident in Catalonia in 2020, the year the Spanish autonomous community had a high incidence of COVID-19.
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Net migration rises to new record figure of 606,000 in the year to December 2022'Some of the language, frankly, has got out of control.' Tory MP RobertBuckland tells KayBurley that 'at times, the tone has not been right', after being asked about the Home Secretary's tone on migration. 📺 Sky 501, Freeview 233 and YouTube
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The impact of metabolic endotoxaemia on the browning process in human adipocytes - BMC MedicineBackground Dysfunctional adipose tissue (AT) is known to contribute to the pathophysiology of metabolic disease, including type 2 diabetes mellitus (T2DM). This dysfunction may occur, in part, as a consequence of gut-derived endotoxaemia inducing changes in adipocyte mitochondrial function and reducing the proportion of BRITE (brown-in-white) adipocytes. Therefore, the present study investigated whether endotoxin (lipopolysaccharide; LPS) directly contributes to impaired human adipocyte mitochondrial function and browning in human adipocytes, and the relevant impact of obesity status pre and post bariatric surgery. Methods Human differentiated abdominal subcutaneous (AbdSc) adipocytes from participants with obesity and normal-weight participants were treated with endotoxin to assess in vitro changes in mitochondrial function and BRITE phenotype. Ex vivo human AbdSc AT from different groups of participants (normal-weight, obesity, pre- and 6 months post-bariatric surgery) were assessed for similar analyses including circulating endotoxin levels. Results Ex vivo AT analysis (lean & obese, weight loss post-bariatric surgery) identified that systemic endotoxin negatively correlated with BAT gene expression (p | 0.05). In vitro endotoxin treatment of AbdSc adipocytes (lean & obese) reduced mitochondrial dynamics (74.6% reduction; p | 0.0001), biogenesis (81.2% reduction; p | 0.0001) and the BRITE phenotype (93.8% reduction; p | 0.0001). Lean AbdSc adipocytes were more responsive to adrenergic signalling than obese AbdSc adipocytes; although endotoxin mitigated this response (92.6% reduction; p | 0.0001). Conclusions Taken together, these data suggest that systemic gut-derived endotoxaemia contributes to both individual adipocyte dysfunction and reduced browning capacity of the adipocyte cell population, exacerbating metabolic consequences. As bariatric surgery reduces endotoxin levels and is associated with improving adipocyte functionality, this may provide further evid
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