Science, Space and Technology News 2024
University of Michigan researchers have discovered that manipulating a protein network in the brain, specifically melanocortin 3 and melanocortin 4, can enhance the effectiveness of GLP-1 drugs, which are used for treating diabetes and obesity.
The class of drugs known as GLP-1 agonists, which includes semaglutides and tirzepatides , have received substantial attention recently for their effectiveness in treating not only type 2 diabetes, but also obesity, heart disease, and potentially addiction. They work by mimicking a natural hormone that the gut produces when it is full, triggering the brain to reduce feeding behavior.
“We found that activating the central melanocortin system hypersensitizes animals to the effects of not just GLP-1s, but to every anti-feeding hormone we tested,” Cone said.
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