Very preterm infants or very low birth weight infants are at higher risk of developing parenteral nutrition-associated cholestasis, finds a study published in BMCPediatr This can be reduced by management of parenteral nutrition in preterm infants.
], which draws more attention from neonatologists. PNAC can be reversed with early intervention conferring a good prognosis. However, failure to initiate the treatment of PNAC in a timely manner will accelerates the disease progression and can lead to liver fibrosis, liver failure and even death.
In recent years, a lot of research has been conducted on identifying risk factors and prevention measures associated with PNAC. It is believed that the occurrence of PNAC is related to preterm birth, low birth weight, infection, prolonged fasting, NEC, extrauterine growth retardation , high intake of amino acids, intravenous fat emulsions, etc. However, the etiology and pathogenesis of PNAC are not yet fully understood.
A total of 465 preterm infants were included in the study . Based on the inclusion criteria, exclusion criteria and PNAC status, preterm infants were assigned to the PNAC group and the non-PNAC group .
]. The severity of Bronchopulmonary dysplasia was assessed at PMA 36 weeks according to the National Institutes of Health criteria, including moderate, FiO
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