Researchers find that early exposure to a Western diet in rats leads to long-lasting impairments in hippocampus-dependent memory, mediated by disruptions in acetylcholine signaling.
By Pooja Toshniwal PahariaApr 18 2024Reviewed by Susha Cheriyedath, M.Sc. In a recent study published in the journal Brain , Behavior, and Immunity , researchers developed an initial-life Western diet murine model associated with long-term hippocampal dysfunction to examine the neurobiological processes underlying these effects.
The study used a relevant Western diet model incorporating dietary choice and macronutrients that simulate a current human WD to investigate whether the gut microbiota functionally associates with early childhood WD-induced memory deficits, possibly through alterations in HPC ACh activity. Researchers explored the role of ACh neurotransmission in the human brain and its possible impact on memory performance. They investigated the amounts of proteins involved in ACh signaling in the HPC and conducted correlational studies between important microbial taxa and VAChT levels. They also explored changes in acute ACh signaling dynamics throughout an episodic memory challenge in CAF versus CTL rats.
Anxiety Brain Chronic Food Hippocampus Immunity Inflammation Receptor
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