Antioxidant supplementation shows potential to improve male fertility Antioxidant Infertility OxidativeStress Stress malefertility supplementation antioxidants_OA Aristoteleio MHB_Fontane
By Suchandrima BhowmikApr 4 2023Reviewed by Benedette Cuffari, M.Sc. A new study in the journal Antioxidants discusses the benefits of antioxidant supplementation in several semen parameters such as motility, morphology, DNA damage, sperm concentration, and fertility rate.
Factors contributing to male infertility include varicocele, which is defined as the enlargement of veins within the scrotum, smoking, radiation exposure, urinary tract infections, nutritional deficiencies, alcohol abuse, psychological stress, strenuous exercise, spinal cord injury, and environmental factors.
ROS and male infertility Spermatozoa consist of a unique plasma membrane structure comprising polyunsaturated fatty acids that improve membrane flexibility for the penetration of oocytes. Following exposure to ROS, lipid peroxidation appears to directly alter the integrity of spermatozoa, which subsequently reduces sperm motility and, as a result, fertility capabilities.
The current study involved searching Cochrane, Medline, and PubMed electronic bibliographies for finding studies concerning the benefits of antioxidants for male infertility. Keywords such as 'antioxidants,' 'sperm function,' 'semen parameters,' 'male infertility,' and others were used for the search, along with several Medical Subject Heading phrases.
The combination of vitamins C and E have been shown to contribute to collagen synthesis and the maintenance of proteoglycans and the intercellular matrix. In one study, one gram of vitamins C and E improved ICSI rates in patients with impaired sperm DNA damage, as well as reduced their rate of DNA damage.
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