Researchers investigated the associations between multikingdom gut microbiome components and functional markers with autism spectrum disorder through metagenomic sequencing of children's fecal samples.
By Vijay Kumar MalesuReviewed by Danielle Ellis, B.Sc.Jul 11 2024 In a recent study published in Nature Microbiology , a group of researchers investigated the associations between multikingdom gut microbiome components and functional markers with autism spectrum disorder through metagenomic sequencing of children's fecal samples.
About the study In the present study, children under 12 years old, both neurotypical and with ASD, were recruited from the Child and Adolescent Psychiatric Clinic between December 2021 and December 2023. ASD diagnosis was based on Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition criteria. Neurotypical children were matched by age and sex and screened using the Chinese Autism Spectrum Quotient Child Version.
Microbial profiles were analyzed using Kraken 2, Bracken, and HUMAnN, with data transformed for microbiome-phenotype association assessments. Machine learning models, trained using random forest classifiers, were tested in independent validation cohorts and public datasets to ensure robustness. Related StoriesAt the functional level, host phenotype factors explained 17.1% and 15.7% of the variation in microbiome pathways and microbial genes, respectively. A diagnosis of ASD ranked as the top factor accounting for variation in both microbiome pathways and microbial genes. After adjusting for confounders, 27 differential Kyoto Encyclopedia of Genes and Genomes Orthology genes and 12 differential pathways were identified.
Children Archaea Atopic Dermatitis Bacteria Brain Dermatitis Diagnostic DNA Fungi Genes Genetic Gut-Brain Axis Hospital Microbiology Microbiome Phenotype Research
United Kingdom Latest News, United Kingdom Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Researchers develop new tool to aid processing of spatial transcriptomic dataResearchers from Children's Hospital of Philadelphia (CHOP) have developed a new tool to help analyze data collected from spatial transcriptomics technologies (SRTs), which simultaneously profile gene expression and spatial location information in tissues to pinpoint which cells in which layers of tissue may drive various diseases.
Read more »
A milestone in epigenetics of reproduction: Researchers crack the male fertility codeEach cell contains a set of instructions in its DNA that determines which genes are expressed and which are silenced. The correct programming of these so-called epigenetic programs, including DNA methylation, is essential for fertilization and development.
Read more »
Researchers ID potential cause behind the blood vessel dysfunction in obesityObesity is a metabolic disorder tied to endothelial dysfunction and increased risk of cardiovascular disease. A recent study, published in the journal Function, investigated the mechanisms responsible for lipid transport and storage interaction with body fat and its impact on metabolic function.
Read more »
Researchers gain insight into little-understood pregnancy complicationUniversity of Liverpool researchers, dedicated to improving the health of women and babies, have led one of the largest studies to understand the premature breaking of waters (PPROM) in pregnant women before 23 weeks' gestation. Their work provides significant insights to help support women, families, and health care professionals.
Read more »
Support, don't micromanage, say researchers who find WFH made some of us neuroticFeeling empowerment and autonomy at work reportedly key when toiling remotely
Read more »
Researchers identify a gene that helps cancer cells spread throughout the bodyMetastatic cancer cells, which cause 90% of cancer-related deaths, must overcome numerous hurdles to spread from a primary tumor through the bloodstream and re-establish themselves in different tissues.
Read more »