Scientists say they have developed an artificial lymph node with the potential to treat cancer, according to a new study in mice and human cells.
Johns Hopkins Medicine scientists say they have developed an artificial lymph node with the potential to treat cancer, according to a new study in mice and human cells. The newly developed lymph node -- a sac filled with immune system components -- is implanted under the skin, and is designed to act like a learning hub and stimulator to teach immune system T-cells to recognize and kill cancer cells.
Johns Hopkins scientists led by Jonathan Schneck, M.D., Ph.D., published research in 2019 showing that hyaluronic acid boosts T-cell activation. "An advantage to this approach over other cell-based therapies such as CAR-T is fewer manufacturing steps," says Schneck, who is a professor of pathology, medicine and oncology at the Johns Hopkins University School of Medicine, director of the Johns Hopkins Center for Translational Immunoengineering, and a member of the Institute for Cell Engineering, Kimmel Cancer Center and Institute for Nanobiotechnology.
Nine days later, mice with melanomas and colon cancers that received a combination of the artificial lymph node, T-cells and the anti-PD-1 drug had the best survival rates , compared with other groups that only lived to about 26 days. This group of mice also had the slowest cancer growth rate. It took between five and 10 days longer for their cancers to double in size than the other groups.
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