Colorectal Cancer & Non-invasive Fecal DNA Testing
insights from industryDr. Yuying WangChief Technology Officer of OncologyBGI Genomics In this interview, NewsMedical speaks with Dr. Yuying Wang, Chief Technology Officer of Oncology from BGI Genomics, about colorectal cancer and the development and application of COLOTECTTM 1.0, a non-invasive fecal DNA test for the detection of colorectal cancer and precancerous lesions.
While most European guidelines recommend average-risk population shall start colorectal cancer screening at age 50, there are now clinical guidelines, such as the American Cancer Society Colorectal Cancer Screening Guideline , recommending colorectal cancer screening at 45 years old instead of 50 years old, because of the concerning increase in colorectal cancer incidence among younger individuals.
Colonoscopy can be quite expensive in some areas of the world, and the procedure is invasive, often resulting in lower adherence due to the relatively lengthy and complicated preparation process. In addition, complications associated with anesthesia may occur. The development of COLOTECTTM 1.0 involved whole-genome bisulfite sequencing of colorectal cancer tumor tissues and paired normal tissues to identify and discover colorectal cancer-associated methylation-specific gene markers.
Overall, its sensitivity for detecting colorectal cancers is 88%, and its specificity for identifying subjects without advanced colorectal neoplasm is 92%.6 Additionally, COLOTECTTM 1.0 has a sensitivity rate of 46% for detecting advanced adenoma cases.6
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