Australian discovery of change in ‘killer T cells’ could help fight against influenza

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Australian discovery of change in ‘killer T cells’ could help fight against influenza
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Research led by the Doherty Institute and UNSW shows that cells are replaced as we get older by ones less able to read threat from infections

A world-first discovery from Australian researchers unlocks the potential for the development of better vaccines and therapies against influenza viruses tailored to different age groups.on Tuesday, has revealed special immune cells called “killer T cells” in older adults closely resemble those found in newborns and children.

And these new cells displayed gene profiles closely similar to T cells found in newborns, which still need to learn how to recognise influenza viruses, van de Sandt said. Prof Katherine Kedzierska of the University of Melbourne, who is head of the human T cell laboratory at the Doherty Institute and a senior author on the paper, said the research will help understand how immunity changes over an individual’s lifespan, which has the potential to significantly advance the science of vaccination.

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