A unique autoantibody signature of multiple sclerosis may predict the disease years before individuals become symptomatic.
Investigators screened blood samples from 250 individuals with MS drawn 5 years before and 1 year after symptom onset, profiled MS-related autoantibodies, and compared the sample with 250 matched controls.
These neurologic episodes may be indicative of ongoing neuroinflammatory processes in the preclinical period, they add. Studies in several other autoimmune diseases show that diagnostic autoantibodies can appear years before symptom onset. However, no such antibodies have previously been identified in MS patients.
Investigators used a technique called phage display immunoprecipitation sequencing to screen human blood for antibodies. Analysis of the collection of peptides, described by the investigators as an"autoantibody signature," was consistent over time and was present regardless of diagnosis. The investigators added that the findings detail some of the first autoantigen-specific biomarkers found in preclinical MS.
Bebo, who was not involved in this research, noted that it was conducted at a single center, is only preliminary, and"has no immediate clinical applicability."
Multiple Sclerosis MS MS - Multiple Sclerosis Healthcare And Medical Technology Health And Medical Tech Health And Med Tech Health And Medical Technology Healthcare Technology Medical Technology Preventive Screening Screening Autoimmune Disease Biomarker Biological Marker Multi-Biomarker Disease Activity MBDA Multibiomarker Disease Activity CSF
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