This article talks about how to accelerate efforts to target the cGAS-STING pathway for autoimmune diseases.
Sponsored Content by BellBrook LabsMay 10 2024Reviewed by Olivia Frost Cyclic GMP-AMP synthase functions as a foreign DNA sensor, triggering an immune response to pathogens by activating the STING receptor. Shortly after its discovery in 2013, abnormal activation of cGAS by self-DNA was found to cause debilitating and often deadly autoimmune disorders, such as systemic lupus erythematosus and Aicardi–Goutieres Syndrome .
Both assays were validated with full-length human cGAS, and pilot screens were performed for cGAS inhibitors using the FP assay. Like other Transcreener assays, the cGAMP assays exhibit the performance qualities required for small-molecule screening, such as sensitivity, robustness , and low levels of compound interference.
Conclusions About BellBrook Labs BellBrook Labs is dedicated to providing scientists with enabling screening tools to accelerate the discovery of more effective therapies. Leveraging its two base platforms, BellBrook has developed easy-to-use assays for hundreds of drug targets. AptaFluor® Biochemical Assay Technology AptaFluor leverages a spit aptamer technology to directly detect SAH, the common product of Methyltransferases. As the most sensitive HTS methyltransferase activity assay available, AptaFluor dramatically reduces enzyme usage and allows the assay to be run at or below Km for SAM.
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