Bending the Rules of Biology: Stanford Scientists Unveil Cellular Origami in Microscopic Predators

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Bending the Rules of Biology: Stanford Scientists Unveil Cellular Origami in Microscopic Predators
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, a remarkable ciliate with its “neck” extended and retracted. Researchers discovered origami-like folds make this morphing possible where microtubules define folding pleats. Credit: Prakash Labextends its structure dramatically, influenced by its cytoskeletal design, promising advances in microscopic technology.

In seconds, a cell that was just 40 microns tip-to-tail sprouted a neck that extended 1500 microns or more out into the world. It is the equivalent of a 6-foot human projecting its head more than 200 feet. All from a cell without a nervous system.because Prakash and Flaum have discovered in this behavior a new geometric mechanism previously unknown in biology.

Specifically, it is a subset of traditional origami known as “curved-crease origami.” It is all based on a structure of thin, helical microtubules – ribs that wrap inside the cell’s membrane. These microtubule ribs are encased in a delicate diaphanous membrane, defining the crease pattern of peaks in a series of mountain-and-valley folds.

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