Alterations in AM function following the exposure to berry-flavored e-cigarettes that lead to poor immune responses to pathogens and reduced host survival.
By Dr. Liji Thomas, MDReviewed by Benedette Cuffari, M.Sc.Nov 7 2024 Exposure alters immune cell movement and reduces pathogen clearance, increasing the risk of severe lung infections.
The innate immune cell signature of the lungs includes cells that regulate the immune response to pathogens like Pseudomonas aeruginosa, which ultimately induce inflammatory cytokines to prevent destructive lung inflammation. Typically, these bacteria are detected, phagocytosed, and cleared by AMs.
In the current study, researchers examined how inhaled berry-flavored e-cigarette vapor affects AM behavior. AM movement was monitored with PKH26, a membrane dye that stains for phagocytes. AM squeezing was reduced to 9%, whereas probing behavior increased to 75%. Increased probe length was also observed, which suggests reduced interalveolar migration in exposed mice. Patrolling behavior dropped from 33% to 21% after exposure.
The adverse effects of BFEV exposure on AM function were reflected in increased bronchoalveolar lavage fluid turbidity and surfactant A post-exposure. However, the berry flavor influenced changes in actin localization and intensity. BFEV exposure also reduced CDC42 levels, a protein that facilitates actin polymerization in the perinuclear area for cell migration.
Actin Alveolar Macrophage Bacteria Capillaries Cell Cigarette Cytokine Cytokines Cytoplasm Inflammation Lungs Macrophage Membrane Nicotine Protein Respiratory
United Kingdom Latest News, United Kingdom Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
More alarming news about the health effects of flavoured vapesThe study showed that specific chemicals in the berry vapes paralyse immune cells in the lungs
Read more »
Mary Berry's Unexpected Twist On Cottage Pie Makes It Even More ComfortingI'm sold.
Read more »
Mary Berry's speedy quiche recipe is ready in under an hourMary Berry has shared a quick and easy recipe for a cheese and onion quiche that uses a clever pastry hack and can be ready in under an hour - perfect for a mid-week meal
Read more »
Heartbeat cast now 31 years since TV debut – including unrecognisable Nick BerryIt's been over 30 years since Heartbeat landed on our TV screens, and 13 years since the final episode of the hit ITV show aired. Where are the cast now? Take a look...
Read more »
Three men deny murder of Rikki Berry, 36Michael Smith, Connor Walsh and Adam Williams are now due to face a trial next year
Read more »
Halle Berry wins court battle over co-parenting therapy with ex Olivier Martinez amid bitter custody...Halle Berry radiates in a red gown ahead of her appearance on 'Jimmy Kimmel Live!' Halle's dress features a wavy strap over her right shoulder, and a spaghetti strap over the left.
Read more »