Scientists from Delft, Vienna, and Lausanne discovered that the protein machines that shape our DNA can switch direction. Until now, researchers believed that these so-called SMC motors that make loops into DNA could move in one direction only.
Delft University of Technology Jan 17 2025 The discovery, which is published in Cell , is key to understanding how these motors shape our genome and regulate our genes.
However, SMC machines don't naturally know which parts to connect. They simply load somewhere on the DNA and start shaping it into a loop until they reach a point where they are forced to stop. That's why they rely heavily on the ability to explore both sides of the DNA to find the right stop signs." Gearbox Biophysicists at Delft University of Technology now found that SMC motors can switch direction, contrary to what was thought to be possible.
Cell Cohesin Genes Genome Nanotechnology Protein Research Technology
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