Researchers reveal that complete blood count setpoints are stable, patient-specific biomarkers that persist for decades, offering new avenues for personalized medicine and precision diagnostics.
By Vijay Kumar MalesuReviewed by Susha Cheriyedath, M.Sc.Dec 12 2024 Discover how stable blood count setpoints unlock the future of personalized diagnostics, reshaping risk assessment and disease prediction for decades.
Background The CBC is a widely used clinical test that evaluates the hematological and immunological state of patients by measuring parameters such as red blood cells , white blood cells , and platelets . It serves as a non-specific diagnostic tool for diverse medical conditions. However, the current interpretation relies on broad, population-wide reference intervals, often insensitive to subtle variations in individual physiology.
To strengthen the validity of the findings, researchers excluded overlapping patients from multiple cohorts and ensured stringent quality control measures. The final cohorts comprised 12,407 patients in Cohort A, 14,371 in Cohort B, and 20,062 in Cohort C. Study Results The analysis of CBC data from three cohorts provided clear evidence of the stability and individuality of hematological setpoints. CBC indices, including RBCs, WBCs, PLTs, HGB, HCT, MCV, MCH, MCHC, MPV, and RDW, exhibited narrow intra-patient variability over 20 years.
This patient-specificity of hematological setpoints underscores their potential in precision medicine. Furthermore, the stability of these setpoints across decades enables the identification of subtle deviations that may indicate early pathological changes.
Diabetes Diagnostic Diagnostics Genetic Healthcare Hemoglobin Medicine Mortality Phenotype Physiology Platelets Precision Medicine Red Blood Cells Research
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