Due to differences in clinical presentation and limited knowledge, diagnosing Sjögren's disease in children can be challenging.
European Alliance of Associations for Rheumatology , EULARJun 14 2024 Due to differences in clinical presentation and limited knowledge, diagnosing Sjögren's disease in children can be challenging. Although dysregulation of multiple immune response pathways has been shown in adults, few studies have investigated pathophysiological mechanisms in children.
Overall, there were 247 differentially expressed genes identified between patients and controls. Of these, 181 were upregulated and 66 downregulated. Gene set enrichment analysis showed enriched gene sets for interferon-gamma and -alpha response, inflammatory response, allograft rejection, fatty acid metabolism, and oxidative phosphorylation. ISG expression was elevated in 72% of children with Sjögren's disease.
Antibodies Blood Children Fever Gene Genes Immune Response Research Rheumatoid Factor Rheumatology Syndrome
United Kingdom Latest News, United Kingdom Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Outlander's Caitriona Balfe visits Blood of My Blood cast in GlasgowCaitriona Balfe surprised her Blood of My Blood co-stars as she dropped by the Outlander spin-off set.
Read more »
Researchers develop new method to remove blood cells in leukemia patients while building new blood systemResearchers have developed an approach to 'deleting' a blood system affected by leukemia while simultaneously building up a new, healthy system with donor blood stem cells. Writing in the journal Nature, the team reports on the promising results obtained in animal experiments and with human cells in the laboratory.
Read more »
Lancashire woman in blood inquiry talks of meeting 'blood friends''I just lost the purpose, why was I living. I was a burden to people, rather than the matriarch of the family, which I was known as.'
Read more »
Infected Blood Inquiry: Parents believe son, 7, was used in secret blood trials before HIV infectionThe long-awaited report into the infected blood scandal will be released on Monday. Colin and Jan Smith, whose beloved son died aged just seven, hope it will lead to some accountability and help shed light on why so many innocent lives were lost.
Read more »
Final NHS infected blood scandal report due as victims await justice decades onPrime Minister Rishi Sunak is widely expected to issue an apology following the publication of the report, which will lay bare the scale of the failings
Read more »
Rishi Sunak set to issue official apology to infected blood scandal victimsThe final report of the infected blood inquiry is due to be published on Monday
Read more »