People who develop long COVID have distinct abnormalities in their immune and hormonal function that can be picked up with blood tests, researchers have found.
Complicating matters, those symptoms vary from one person to another—as does the duration. Some people have persistent symptoms for weeks to months after their initial bout of COVID; others are still waiting for a resolution years out.applied a machine-learning algorithm to nearly 35,000 patients' electronic health records to distinguish four major subtypes of long COVID.
Fei Wang, the researcher on that study, said that given the broad spectrum of long COVID symptoms, it's important to nail down whether they arise randomly or tend to occur in definable clusters. The study cannot prove those markers—the reactivated viruses, the low cortisol, the abnormal T cell activity—are causes of long COVID, Wang said. But, he added, they raise the possibility.
Putrino's team analyzed all participants' blood samples—which, on average, were taken one year after COVID patients' initial infection. They detected a number of differences in the study groups' blood biomarkers. Based on those biomarkers, awas able to distinguish patients with and without long COVID with 96% accuracy.
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