A team of chemists has achieved a significant breakthrough in the field of chemical synthesis, developing a novel method for manipulating carbon-hydrogen bonds. This groundbreaking discovery provides new insights into the molecular interactions of positively charged carbon atoms.
By selectively targeting a specific C--H bond, they open doors to synthetic pathways that were previously closed -- with potential applications in medicine.
This process involves breaking and forming bonds between atoms. Some bonds, such as those between carbon and hydrogen , are particularly strong and require considerable energy to break, while others can be more easily modified. Whereas an organic compound typically contains dozens of C-H bonds, chemists traditionally had to resort to manipulating other, weaker bonds.
The Maulide group focuses on so-called"carbocations" as key intermediates."Traditionally, carbocations react by eliminating a hydrogen atom adjacent to the carbon atom, forming a carbon-carbon double bond in the product," explains Nuno Maulide."Products with double bonds -- called alkenes -- can be extremely useful. However, sometimes a single bond instead of a double bond is desired," continues the multiple ERC awardee.
The carbon-hydrogen bonds in alkanes -- particularly those at the ends of the molecules, where each carbon has three hydrogen atoms bound to it -- are very hard to 'crack' if you want to replace the ...
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Breaking bonds to form bonds: New chemical reaction with potential applications in medicinal chemistryA team of chemists from the University of Vienna, led by Nuno Maulide, has achieved a significant breakthrough in the field of chemical synthesis, developing a novel method for manipulating carbon-hydrogen bonds. This discovery provides new insights into the molecular interactions of positively charged carbon atoms.
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