Scientists developed a human pancreatic cancer fibrotic barrier 3D cell-culture model to assess treatments for pancreatic ductal adenocarcinoma. By targeting the ROCK2 pathway, they achieved a notable decrease in fibrosis and enhanced tissue permeability to drugs, offering promising avenues for overcoming treatment obstacles in pancreatic cancer.
Researchers develop a human pancreatic cancer fibrotic barrier 3D model to mimic human conditions for assessing treatment strategies in pancreatic cancer
Understanding the underlying mechanisms driving fibrosis is essential in advancing treatment strategies for this devastating illness. The conventional models used for studying pancreatic ductal adenocarcinoma fibrotic environment often fail to accurately mimic the complexity of the disease. Seeking a more clinically relevant approach, a team of researchers led by Professor Mitsunobu R.
Looking ahead, the implications of the study extend beyond pancreatic cancer alone."Fibrosis is prevalent not only in pancreatic cancer but also in other cancers that are difficult to treat, such as those affecting the stomach, breast, and lung, as well as in some non-cancerous diseases.
Cancer Lung Cancer Cystic Fibrosis Diseases And Conditions Breast Cancer Colon Cancer Lymphoma
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