A discovery by a three-member Albert Einstein College of Medicine research team may boost the effectiveness of stem-cell transplants, commonly used for patients with cancer, blood disorders, or autoimmune diseases caused by defective stem cells, which produce all the body's different blood cells.
Albert Einstein College of Medicine Aug 8 2024 A discovery by a three-member Albert Einstein College of Medicine research team may boost the effectiveness of stem-cell transplants, commonly used for patients with cancer, blood disorders, or autoimmune diseases caused by defective stem cells , which produce all the body's different blood cells. The findings, made in mice, were published today in the journal Science.
Mobilizing stem cells Stem-cell transplants treat diseases in which an individual's hematopoietic stem cells have become cancerous or too few in number . The therapy involves infusing healthy HSCs obtained from donors into patients. To harvest those HSCs, donors are given a drug that causes HSCs to mobilize, or escape, from their normal homes in the bone marrow and enter the blood, where HSCs can be separated from other blood cells and then transplanted.
After mixing HSCs with macrophages, the researchers discovered that some HSCs engaged in trogocytosis, a mechanism whereby one cell type extracts membrane fractions of another cell type and incorporates them into their own membranes. Those HSCs expressing high levels of the protein c-Kit on their surface were able to carry out trogocytosis, causing their membranes to be augmented with macrophage proteins-;and making them far more likely than other HSCs to stay in the bone marrow.
Related StoriesThe researchers intend to continue their investigation into this process: "Our ongoing efforts will look for other functions of trogocytosis in HSCs, including potential roles in blood regeneration, eliminating defective stem cells and in hematologic malignancies," added Dr. Will.
Blood Bone Bone Marrow Cancer Cell Biology Drugs Laboratory Leukemia Medicine Myelodysplastic Syndromes Ph Research Stem Cells Students
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