A team of researchers from the Hebrew University of Jerusalem, the Weizmann Institute of Science, and the University of Tokyo has made a significant breakthrough in the fight against cancer by developing a highly selective inhibitor for an enzyme called Matrix Metallopeptidase 7 (MMP7).
Hebrew University of JerusalemOct 18 2024 A team of researchers from the Hebrew University of Jerusalem, the Weizmann Institute of Science, and the University of Tokyo has made a significant breakthrough in the fight against cancer by developing a highly selective inhibitor for an enzyme called Matrix Metallopeptidase 7 . This enzyme plays a crucial role in cancer progression, especially in helping tumors invade surrounding tissues and spread to other parts of the body .
Led by Professor Norman Metanis and PhD student Hiba Ghareeb from the Hebrew University, in collaboration with Professor Irit Sagi from the Weizmann Institute of Science and Professor Hiroaki Suga from the University of Tokyo, the study utilized a pioneering approach called Mirror-Image Random Nonstandard Peptide Integrated Discovery .
One of the standout peptides discovered in this study, named D'20, was designed in a unique mirror-image form. This peptide is made up of twelve specially modified building blocks called D-amino acids, along with other structural elements, making it both stable and highly specific. In laboratory tests, D'20 demonstrated impressive ability to block MMP7 activity with a high degree of precision, without affecting other enzymes that have similar functions.
The stability of D'20 was also remarkable—it retained its structure and function in human blood and in conditions that simulate the digestive system, suggesting it has great potential for further development as a drug. This level of stability is key in ensuring that the peptide can work effectively in the human body over time.
This research not only offers new hope for targeting MMP7 in cancer therapy but also showcases the power of mirror-image random peptide discovery technology in developing new treatments. By creating highly specific and stable peptides, the team has opened up exciting possibilities for treating aggressive cancers, like pancreatic cancer, and improving the outlook for patients facing these difficult diseases.Journal reference:Metanis, N., et al. .
Cancer Treatment Drugs Enzyme Metastasis Pancreatic Cancer Peptides Research Technology
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