Blocking IL-11 signaling extends lifespan and healthspan in mice, reducing age-related metabolic decline, frailty, and cancer incidence.
By Dr. Chinta SidharthanReviewed by Susha Cheriyedath, M.Sc.Jul 18 2024 In a recent study published in the journal Nature, a team of researchers used murine models and various pharmacological and genetic approaches to examine whether pro-inflammatory signaling involving interleukin -11, which activates signaling molecules such as extracellular signal-regulated kinase and mammalian target of rapamycin complex 1 , was negatively associated with health- and lifespan.
Studies in animal models such as fruit flies, yeast, and worms have explored lifespan extension. However, the findings from these studies cannot directly be applied to healthspan since lifespan extension cannot be equated with improved healthspan. Therefore, it is important to explore the impact of various interventions on lifespan and health span separately. In this respect, mice are suitable models as they exhibit aging pathologies similar to those of humans.
For this study, the researchers used mouse models and human hepatocyte cultures. Primary human hepatocytes were cultured and then stimulated with IL-11 for varying durations. The supernatants from these stimulated cells were then used for proximity extension assays using an inflammation panel consisting of 92 proteins.
Related StoriesLifespan and tumor progression were monitored after the mice were intraperitoneally injected with IgG or anti-IL-11 antibodies. The animals were also subjected to glucose and insulin tolerance tests, and echo magnetic resonance imaging was used to analyze their body composition. Results The study found that in aging mice, the expression of IL-11 was upregulated in various types of cells and tissues and that the deletion of either the gene coding for IL-11 or the IL-11 receptor's alpha 1 subunit protected the mice against metabolic decline, frailty, and multimorbidity as they aged.
Research Adenosine Antibodies Cancer Cytokine Cytokines Fruit Gene Genetic Inflammation Interleukin Kinase Liver Muscle Protein Rapamycin Receptor Serine Threonine Yeast
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