Australian cancer researchers are the first to establish a next-generation gene-editing tool for modeling and interrogating human disease.
La Trobe UniversityJan 31 2025
The researchers were also able to identify genes that led to accelerated lymphoma growth in the pre-clinical model by using unique Cas12a-compatible mouse whole-genome CRISPR "libraries". Postdoctoral Researcher at the ONJCRI and WEHI Dr. Eddie La Marca, who is a co-lead author on the paper published in Nature Communications today, said:
Related Stories"We have also crossed our Cas12a animal model with a model that expresses an altered version of Cas9, allowing us to both delete and activate different genes simultaneously. This will allow researchers to use this tool to model and interrogate complex genetic disorders."
Gene Gene-Editing Medical Research Research Cancer Treatment Cas9 CRISPR DNA Enzyme Genes Genome Hospital Lymphoma Medicine RNA Technology
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