The natural world is rich in chemical compounds with remarkable medicinal properties. A notable example is penicillin, discovered by chance from the Penicillium mold.
Tokyo University of ScienceAug 9 2024 This discovery revolutionized the treatment of bacterial infections and highlighted the potential of natural compounds in medicine. Since then, the identification, isolation, and synthesis of novel bioactive compounds from plants, fungi, and bacteria have become fundamental to drug development.
In a recent study, researchers from Tokyo University of Science , led by Associate Professor Takatsugu Murata and Professor Isamu Shiina from the Department of Applied Chemistry, Faculty of Science, have made significant progress by developing an efficient method to synthesize eutyscoparol A and violaceoid C. Their work, featured on the cover of Volume 13, Issue 7 of the Asian Journal of Organic Chemistry, and published on 25 April 2024, could lead to new treatments or drugs.
The researchers used a retrosynthetic analysis to simplify the production process. This approach breaks down complex molecules into simpler, more accessible materials. They used this method to synthesize eutyscoparol A and violaceoid C starting from commercially available dinitriles through violaceoid A intermediates. Dinitriles were chosen because they are easy to obtain and can be converted into aldehydes , which are precursors to violaceoid A intermediates.
Related StoriesThese improvements made the process much more efficient. The researchers synthesized violaceoid A in 8 steps with a 33% yield, compared to the previous 10-step process that had only an 11% yield. Similarly, they prepared rac-violaceoid B in 8 steps with a 35% yield, improving on the earlier 9-step process with a 15% yield.
Alcohol Aldehydes Bacteria Drugs Medicine Mold Organic Chemistry Penicillin Research Technology
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