Inside every cell, a network of tiny filaments, called the microtubule cytoskeleton, helps maintain the cell's shape, allows it to divide, and transports vital materials from one part of the cell to another.
Institute for Research in Biomedicine Oct 15 2024 Inside every cell, a network of tiny filaments, called the microtubule cytoskeleton, helps maintain the cell's shape, allows it to divide, and transports vital materials from one part of the cell to another. The filaments that form this network, termed microtubules, are hollow tubes that act as scaffold structures and transport tracks.
This work is a beautiful example of how visualizing individual molecules at high-resolution using cryo-EM and the subsequent processing of this information using neural network-based algorithms can reveal large molecules in action and how they work." Building the cell's framework Microtubules are like scaffold structures, and just like when constructing a building, the cell needs to assemble them in the right places, in the right orientation, and at the right times.
The power of advanced imaging To uncover this mechanism, the team used cryo-electron microscopy , a cutting-edge technique that allows scientists to capture high-resolution images of purified macromolecular complexes such as gTuRC. Through cryo-EM, they were able to observe how CDK5RAP2 binds to γTuRC, triggering structural changes in the complex. These detailed images provided unprecedented insights into how the complex adopts microtubule-like symmetry.
Actin Biomedicine Cancer Cell Chemotherapy Cytoskeleton Research
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