In a report published in The Lancet Infectious Diseases (Safety and efficacy of PfSPZ Vaccine against malaria in healthy adults and women anticipating pregnancy in Mali: two randomized, double-blind, placebo-controlled, phase 1 and 2 trials) a team led by investigators at the Malaria Research and Training Center (MRTC), Bamako, Mali; the...
Sanaria Inc.Aug 14 2024 In a report published in The Lancet Infectious Diseases a team led by investigators at the Malaria Research and Training Center , Bamako, Mali; the Laboratory of Malaria Immunology and Vaccinology , National Institute of Allergy and Infectious Diseases , National Institutes of Health; and Sanaria Inc. describes the durable protective efficacy against malaria shown by Sanaria® PfSPZ Vaccine when administered to women prior to pregnancy.
Better protection for the mother and developing fetus is urgently needed. PfSPZ Vaccine has an excellent safety profile and our teams have worked with NIH and Sanaria partners over the years to demonstrate its efficacy in Mali, where seasonal malaria transmission is intense." This trial recruited women who were planning to get pregnant in the coming year. After immunization, birth control was stopped in most and the women were followed through two malaria transmission seasons over nearly two years. Those who became pregnant were followed throughout their pregnancies, and newborns were followed up to their first birthday to measure long-term outcomes.
Related StoriesAn unexpected finding was that pregnancy was detected earlier in the vaccine group than placebo. Although this effect had marginal statistical significance, it suggested that malaria infection likely aborts many early pregnancies before they are detected. By preventing these early infections, vaccinated women appeared to become pregnant sooner.
Vaccine Allergy Conception Efficacy Immunization Immunology Infectious Diseases Laboratory Placebo Plasmodium Falciparum Pregnancy Research
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