Researchers from the University of Bonn are using an innovative method to watch immune receptors go about their business.
University of BonnNov 12 2024
They work like the olfactory receptors in our nose, being activated when they encounter a specific chemical signal. The alarm that they trigger starts a series of reactions inside the cells. When scavenger cells "sniff out" a bacterium, for instance, they initiate a process known as phagocytosis by engulfing and digesting it, while other immune cells release special messengers that call for reinforcements and thus provoke inflammation.
Researchers usually attempt to answer this question by marking molecules in a different color, which tells them, for example, when the receptor switches on a certain signaling pathway in which these molecules play an important role. However, this method is very time-consuming and laborious and requires the observer to be very familiar with the signaling pathways already.
Cell Cell Wall Dementia Diabetes Drugs E. Coli Hospital Immune Response Immune System Infectious Diseases Molecule Receptor Research Salmonella
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