Researchers say the results mark the first time a vaccine - known as a neoantigen DNA vaccine - has shown such positive results in a clinical trial.
Breast cancer patients have been given a new hope following the discovery of a ground breaking new vaccine which has sparked "promise" in battling an aggressive strain of the disease.
The vaccine was praised for being "well-tolerated" and initiating significant immune reactions. In the study, 18 participants faced with non-metastatic triple-negative breast cancer were given standard treatment along with three bespoke vaccine doses, each engineered to target specific tumour mutations and prime immune cells to destroy aberrant cells carrying those changes.
Study senior author Professor William Gillanders, from Washington University School of Medicine, expressed optimism about the trial results for a new vaccine strategy against triple-negative breast cancer, calling findings "better than we expected". Gillanders also noted: "We are encouraged by what we’re seeing with these patients so far." The aggressive nature of triple-negative breast cancer, which lacks targeted therapies and is usually treated with surgery, chemotherapy, and radiation therapy, makes the search for effective treatments crucial.
Each patient's vaccine included an average of 11 neoantigens, with a range from four to 20, tailored to their specific tumour. A paper published concurrently details the software tools created by the team, which aim to be accessible to cancer researchers and clinicians globally. Griffith further explained: "The tools rank the possible neoantigens based on our current knowledge of what matters in stimulating the immune system to attack cancer cells." The software tools, supported by the National Cancer Institute, are open-license, making them widely available for both academic and commercial use.
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