Resulting atlas of the aging human brain holds molecular insights into the brain's vulnerability and resilience.
Less than a decade ago, when Dr. Hansruedi Mathys launched an ambitious project to create an annotated library of all the gene readouts stored within 100 individual brain cells, the task felt daunting.
Mathys, who pioneered single-cell transcriptomic analysis on post-mortem human brain tissue during his postdoctoral training and is now an assistant professor of neurobiology at the University of Pittsburgh School of Medicine, says that the resulting atlas of the aging human brain holds molecular insights into the brain's vulnerability and resilience.
By tracking how transcriptomic changes are linked to cognitive decline and Alzheimer's pathology, Mathys and his colleagues discovered that astrocytes -- one of the cell types that make up the brain tissue scaffold alongside maintaining a host of other crucial functions -- could be holding a key to cognitive resilience.
Investigators have assembled the most comprehensive atlas to date of messenger RNA variants in the mouse and human brain. The atlas is an important new resource in understanding brain ...
Alzheimer's Research Nervous System Healthy Aging Dementia Intelligence Alzheimer's Brain-Computer Interfaces
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